By Sarah A LoBisco, ND
TIME FOR TOP READS.......
Pull up your laptop, grab your chamomile tea, click on your classical music, and enjoy my summaries on some of the biggest headlines in health from August! You can get the full summary here.
THE STATIN STORY CONTINUES:
According to Dr. Fryhofer of Medscape:
As many as 10% of patients on statin therapy suffer muscle-related adverse effects. There are several proposed statin-induced mechanisms:
- Decreases in cholesterol content of skeletal muscle membranes making them unstable and thus more prone to injury;
- Depletion of coenzyme Q10 with subsequent deleterious effects on mitochondrial function; and
- Reduced bioavailability of isoprenoids (farnesyl pyrophosphate and geranyl pyrophosphate), which can lead to cell death in vitro.
Risk is highest for women, older patients, patients on high statin doses, people with a family history of statin intolerance, and patients on multiple medications.
Genetics can also play a role, as well as which statin:
A recent study showed carriers of the SLCO1B1 gene polymorphism had increased risk for muscle-related statin adverse effects. The greatest risk was seen in patients on simvastatin, whereas the risk for patients on pravastatin was almost negligible.
Bringing us to highlight number one:
In early June 2011, the US Food and Drug Administration (FDA) issued a drug safety communication on the 80-mg dose of simvastatin because of an increased risk for muscle toxicity. Medscape interviewed Amy Egan, MD, MPH, Deputy Director for Safety in the Division of Metabolism and Endocrinology Products at the FDA, regarding these warnings and their impact. Doctors are encouraged to use different brands, not dose past 40mg and consider it's interactions with other medications.
Sandra A. Fryhofer, MD. Switching From Simvastatin 80 mg: How to Shop for Statins: The Simvastatin Saga: Review of the FDA Drug Safety Warnings. Medscape Today. Accessed August 17, 2011. http://www.medscape.com/viewarticle/747821_2
Michael O'Riordan. FDA Restricts Use of Simvastatin 80 mg. Medscape Today. Posted: 06/08/2011
BLOOD SUGAR, STATINS, & DIET
In my July Top Reads, I gave references to how statins could contribute to diabetes. (YICKS: achy muscles and blood sugar problems).
This month, a study demonstrated how diet can affect diabetes, actually, reverse it!
Reversing Diabetes 2 with Diet (diabetologia)
Conclusions/interpretation: Normalisation of both beta cell function and hepatic insulin sensitivity in type 2 diabetes was achieved by dietary energy restriction alone. This was associated with decreased pancreatic and liver triacylglycerol stores. The abnormalities underlying type 2 diabetes are reversible by reducing dietary energy intake
DOCTOR SARAH, DO I REALLY NEED SUPPLEMENTS??? I EAT WELL!!
I'll refer to an older and wiser mentor to many:
It is true ONLY if you work and live outside, breathe only fresh unpolluted air, drink only pure, clean water, sleep nine hours a night, move your body every day, and are free from chronic stressors and exposures to environmental toxins. Then you don't need vitamins.
Today, even with our "enriched food," more than 92 percent of Americans are deficient in one or more vitamins. That doesn't mean they are receiving less than the amount they need to get for optimal health. That means they receive less than the MINIMUM amount necessary to prevent deficiency diseases. In a study published in the Journal of the American College of Nutrition, researchers found that 6 percent of those tested had serious vitamin C deficiency and 30 percent were borderline low. A USDA survey showed that 37 percent of Americans don't get enough vitamin C, 70 percent not enough vitamin E, almost 75 percent don't get enough zinc, and 40 percent don't get enough iron. I would say that 100 percent of us don't have enough of the basic nutrients to create optimal health or give ourselves a metabolic tune up.
Read more on TOP READS on the value of supplementing! J
AND, FINALLY....WHAT ABOUT GERD???
TWO (2) things:
A reference on the link between the use of GERD Medications and Cancer
CONCLUSIONS: Medically treated patients with mild or absent GERD symptoms have significantly higher odds of adenocarcinogenesis compared with medically treated patients with severe GERD symptoms. This finding may explain the failure of the current screening paradigm in which the threshold for primary endoscopic examination is based on symptom severity.
A few links below under WHAT'S HAPPENIN'" to my responses on Dr. Oz's Sharecare relating to GERD.
WHAT'S HAPPENIN' AT THE CLINIC????????
1. NEXT HEALTH FORUM: OCTOBER 6th at 6:15pm
Join me and a community of like-minded individuals in an interactive and engaging discussion about the latest topics and issues in integrative, alternative, conventional, and natural medicine. Find out more here.
2. SHARCARE: GOT GERD?
Follow my latest answers and blogs as a featured expert on Dr. Oz's Sharecare relating to:
3. WOMEN AND MEDICINE: PREVENTION HIGHLIGHTED
Click the link on my homepage to learn about new strategies to increase supportive and preventative care for women. (Issued from the Institute of Medicine).
W WHAT ELSE IS ON MY HOMEPAGE?
As usual, I'm always adding new resources to my homepage, so you all have a one stop shop of referrals. Here are some highlights:
· Organic Trade Association (OTA)
· Personal Care Products-Don't Put that on Your Face
· Produce: How Dirty is Yours?
· Soy Summary 2
· Do Vaccines Work?(The Atlantic)
· Flu Vaccine Pros and Cons
· Gardasil and Menctra
· Hepatitis B Vaccine Side Effects Study
.........UNTIL WE READ AGAIN! J